Buy Humanin Peptide

Humanin is a small peptide that plays a critical role in cellular protection, particularly by defending cells against stress-induced damage and apoptosis. Research suggests it may have potential health benefits, including protective effects against neurodegenerative diseases like Alzheimer’s and possible anti-aging properties due to its influence on mitochondrial function. Current, ongoing, studies continue to explore its therapeutic potential, focusing on its ability to modulate oxidative stress, inflammation, and age-related cellular decline.

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Humanin Pre-Mixed Pen 10mg
£52.09 – £140.64 Select options This product has multiple variants. The options may be chosen on the product page
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Humanin Peptide Vial 10mg
£21.52 – £30.41 Select options This product has multiple variants. The options may be chosen on the product page
Humanin Nasal Spray
£49.34 – £93.68 Select options This product has multiple variants. The options may be chosen on the product page

Which Humanin Product is Right for You?

PharmaGrade.Store United Kingdom supplies a variety of Humanin peptide products for research purposes only, including:

- Humanin Peptide Vial – White lyophilized Humanin, supplied in a sterile glass vial for flexible research dosing. Please note you also require bacteriostatic water to reconstitute your peptide before use. Available in 10mg peptide vials.
- Humanin Nasal Spray – pre-mixed and ready to use Humanin solution for administration via the nasal cavity. Choose from 15ml or 30ml nasal sprays here.
- Humanin Pre-Mixed Peptide Pen – Humanin Peptide Pen kits and cartridges come ready to use pre-mixed with Humanin peptide and bacteriostatic water. Buy Humanin 10 mg Buy Humanin 10mg Pre-Mixed Peptide.

Buy Humanin for Research Purposes

Humanin (HN) is a small protein produced in the mitochondria, the cell’s energy hubs, and is encoded by the mitochondrial DNA’s 16S ribosomal RNA gene. The Humanin peptide functions through several mechanisms of action, primarily focused on cellular protection and survival. It interacts with specific receptors, such as the formyl peptide receptor-like 1 (FPRL1) and the trimeric receptor complex CNTFR/WSX1/gp130, to activate intracellular signalling pathways [1].

These pathways trigger protective responses, including the inhibition of apoptosis (programmed cell death). By blocking pro-apoptotic proteins like Bax and Bid, Humanin ensures cellular integrity under stress conditions.

Additionally, Humanin influences mitochondrial function, a key factor in aging and energy metabolism. It helps regulate oxidative stress by maintaining mitochondrial homeostasis, reducing the harmful effects of free radicals. This contributes to improved cellular resilience and reduced inflammation [2].

United Kingdom Studies have found that it’s neuroprotective effects are particularly notable. Humanin has been found to protect neurons from toxins associated with the progression of Alzheimer’s disease, such as amyloid-beta [3].

Furthermore, United Kingdom studies have indicated enhanced Humanin levels play a role in metabolic regulation, potentially improving insulin sensitivity and counteracting age-related metabolic decline [4].

Humanin Peptide Benefits

United Kingdom Clinical studies have indicated that Humanin peptide could have the following applications:

Neuroprotective properties: Humanin may help protect neurons from toxins like amyloid-beta, showing promise in treating neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease [3].
Anti-aging effects: Studies have found that Humanin enhances mitochondrial function, reduces oxidative stress, and mitigates age-related cellular damage, potentially slowing the aging process indicating longevity [4].
Metabolic regulation: Improves insulin sensitivity and aids in managing glucose levels, making it a candidate for treating diabetes and metabolic syndrome [4].
Cardiovascular health: Reduces inflammation and oxidative stress, thereby supporting heart health and preventing cardiovascular diseases including heart disease [4].
Cell survival: Humanin protects various cell types from stress-induced damage and apoptosis, boosting cellular resilience under adverse conditions [5].
Inflammation control: Modulates inflammatory responses, contributing to overall immune system regulation and reduced chronic inflammation [6].
Mitochondrial homeostasis: Regulates mitochondrial activity and promotes energy balance, critical in preventing age-related and chronic diseases [3].
Potential in cancer therapy: Shows promise in protecting healthy cells during chemotherapy while maintaining its anti-apoptotic effects [7].

Scientific Research Humanin United Kingdom

Humanin peptide, discovered in 2001, has been a focus of intense scientific research due to its protective role in cellular health. United Kingdom Studies highlight its potential in neuroprotection, where it shields neurons from toxins linked to Alzheimer’s and Parkinson’s diseases [2].

United Kingdom Studies on Humanin also shows it has promise in anti-aging research, enhancing mitochondrial function and reducing oxidative stress, key factors in cellular aging [4] . Investigations into its metabolic benefits suggest improved insulin sensitivity and potential for diabetes management [8].

Whilst preclinical studies demonstrate its therapeutic promise, challenges remain in translating these findings into clinical applications, including dosage optimization and long-term safety evaluation. Research continues to explore its vast potential.

Humanin Specifications:

View PharmaGrade Store United Kingdom Humanin HPLC Certificate here.

Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

Molecular Formula: C121H205F3N34O34S2

Buy Humanin Peptide United Kingdom online for research use from PharmaGrade.Store today! PharmaGrade.Store is a trusted online supplier of clinical grade peptides with worldwide shipping.

Frequently Asked Questions about Humanin Peptide United Kingdom

Can Humanin peptide benefit the immune system?

Humanin peptide does appear to have potential benefits for the immune system. It is known for its protective effects on various cell types, including leukocytes, which are crucial components of the immune system. By enhancing mitochondrial function and reducing oxidative stress, Humanin may help maintain cellular health and resilience, which is vital for a robust immune response. Additionally, its ability to protect cells from apoptosis and other stressors suggests it could support immune system function by preserving the health and viability of immune cells [2].

Can Humanin be a potential treatment for obesity?

Humanin may be a promising candidate in the treatment for obesity, particularly in mid-life. United Kingdom Studies suggest that Humanin treatment can help mitigate obesity that typically develops during mid-life without worsening the natural decline in metabolic function. Additionally, research involving diet-induced obesity models in mice indicates that Humanin, along with other peptides, can influence metabolic profiles, suggesting a role in weight management. However, more research is needed to fully understand its efficacy and mechanisms in humans [9].

How can the humanin peptide have an effect on the glucose metabolism?

Humanin peptide can influence glucose metabolism in several ways:

Enhancing Insulin Sensitivity: Humanin has been shown to improve insulin sensitivity in both the liver and skeletal muscle, which helps in better regulation of blood glucose levels.
Improving Glucose-Stimulated Insulin Secretion (GSIS): Studies indicate that Humanin analogs can increase GSIS, which is crucial for maintaining normal blood sugar levels [10].
Supporting Pancreatic Beta Cells: Humanin may improve the survival of pancreatic beta cells, which are responsible for insulin production, thereby potentially delaying the onset of diabetes [8].

These effects suggest that Humanin could play a role in managing glucose metabolism and potentially aid in the treatment of metabolic disorders like diabetes.

What is peptide synthesis?

Peptide synthesis is the process of creating peptides, which are compounds made up of multiple amino acids linked together by peptide bonds (amide bonds). This process involves coupling the carboxyl group of one amino acid to the amino group of another, forming a chain that can range from small peptides to large proteins. Various techniques and procedures are used in peptide synthesis, including solid-phase synthesis and solution-phase synthesis, to produce these chains efficiently.

Blogs:

P-21 Peptide: Enhancing Brain Function and Fighting Cancer

This blog discusses the P-21 peptide, highlighting its potential in enhancing cognitive function and its promising role in cancer therapy. P-21 is a neuropeptide that has garnered attention for its ability to improve brain functions and provide neuroprotection. It interacts with brain receptors to boost cognition and memory, and shows potential in targeting tumour cells, inhibiting their growth without affecting normal cells. The peptide’s mechanisms include inhibiting cyclin-dependent kinases, which disrupts cell cycles, offering therapeutic avenues in cancer treatment. The blog emphasizes ongoing research into P-21’s multifaceted applications in both neurology and oncology.

Read on here.

Unlocking the Power of NAD+ Supplements: A Guide to Anti-Aging and Cellular Health

The blog explores the benefits of NAD+ supplements for anti-aging and cellular health. It highlights NAD+ as a crucial coenzyme involved in energy production, DNA repair, and cellular signalling, and explores other similar peptides like Humanin.

As NAD+ levels decline with age, supplementation is suggested to restore these levels, potentially delaying aging and improving health outcomes. The blog also discusses how NAD+ supports mitochondrial function, enhances cognitive abilities, and promotes cardiovascular health. It also covers the role of NAD+ in activating sirtuins, proteins that regulate lifespan and metabolic health.

Scientific Research:

[1] Yen K, Lee C, Mehta H, Cohen P. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013 Jan 11;50(1):R11-9.

[2] Coradduzza, D.; Congiargiu, A.; Chen, Z.; Cruciani, S.; Zinellu, A.; Carru, C.; Medici, S. Humanin and Its Pathophysiological Roles in Aging: A Systematic Review. Biology 2023, 12, 558.

[3] Karachaliou CE, Livaniou E. Neuroprotective Action of Humanin and Humanin Analogues: Research Findings and Perspectives. Biology (Basel). 2023 Dec 16;12(12):1534.

[4] Rochette L, Meloux A, Zeller M, Cottin Y, Vergely C. Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders. Arch Cardiovasc Dis. 2020 Aug-Sep;113(8-9):564-571.

[5] Coradduzza D, Congiargiu A, Chen Z, Cruciani S, Zinellu A, Carru C, Medici S. Humanin and Its Pathophysiological Roles in Aging: A Systematic Review. Biology (Basel). 2023 Apr 6;12(4):558.

[6] Zhao Y, Mäkitie O, Laakso S, Fedosova V, Sävendahl L, Zaman F. A novel link between chronic inflammation and humanin regulation in children. Front Endocrinol (Lausanne). 2024 Jan 23;14:1142310.

[7] Peña Agudelo JA, Pidre ML, Garcia Fallit M, Pérez Küper M, Zuccato C, Nicola Candia AJ, Marchesini A, Vera MB, De Simone E, Giampaoli C, Amorós Morales LC, Gonzalez N, Romanowski V, Videla-Richardson GA, Seilicovich A, Candolfi M. Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells. Cancers (Basel). 2023 Aug 11;15(16):4061.

[8] Boutari C, Pappas PD, Theodoridis TD, Vavilis D. Humanin and diabetes mellitus: A review of in vitro and in vivo studies. World J Diabetes. 2022 Mar 15;13(3):213-223.

[9] Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K. Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics. 2019 Jun 6;15(6):88.

[10] Kuliawat R, Klein L, Gong Z, Nicoletta-Gentile M, Nemkal A, Cui L, Bastie C, Su K, Huffman D, Surana M, Barzilai N, Fleischer N, Muzumdar R. Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB J. 2013 Dec;27(12):4890-8.

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